Total Synthesis of Indolizidine Alkaloid (±)-Bipolamine I
نویسندگان
چکیده
Key words (±)-bipolamine I - indolizidine alkaloids ring-closing metathesis Barton–McCombie deoxygenation samarium(II) iodide
منابع مشابه
Total synthesis of the indolizidine alkaloid tashiromine
BACKGROUND Tashiromine 1 is a naturally occurring indolizidine alkaloid. It has been the subject of thirteen successful total syntheses to date. Our own approach centres on the stereoselective construction of the indolizidine core by capture of an electrophilic acyliminium species by a pendant allylsilane. The key cyclisation precursor is constructed using olefin cross-metathesis chemistry, whi...
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Concise and highly stereocontrolled total syntheses of racemic and enantiopure frog alkaloid 205B (1) were accomplished in 11 steps from 4-methoxypyridines 6 and 7 in overall yields of 8 and 8%, respectively. The assembly of the core of the natural product relies on a stereoselective Tsuji-Trost allylic amination reaction and a ring-closing metathesis. The synthesis features the use of an N-acy...
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ژورنال
عنوان ژورنال: Synfacts
سال: 2022
ISSN: ['1861-194X', '1861-1958']
DOI: https://doi.org/10.1055/s-0042-1752951